Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective study
Hickling KG, Henderson S, Jackson R. Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective study. Critical Care Medicine. 1994;22:1568–1578.
This study suggests that using low tidal volumes with permissive hypercapnia to limit peak inspiratory pressure and reduce regional lung overdistension can decrease the incidence of ventilator-induced lung injury.
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